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A: Narcotics have a pretty good safety record in pregnancy; however, there is some risk, and the first trimester is the riskiest in affecting development of your baby. Lortab (hydrocodone) is related to codeine. It is Category C, therefore it shouldn't be used unless you're devastated by the fibroid pain. But that's my cautious statement. If a patient were to come to me having already used it, I wouldn't be in a panic. I'd just use extra ultrasound, which would also be helpful in following your fibroids, which rarely can grow during pregnancy.