RhoGam or rho-immunoglobulin (also called anti-Rh or anti-D immunoglobulin) is an injectable blood product used to protect an Rh-positive fetus from antibodies by its Rh-negative mother. The idea underlying Rhogam is if anti-Rh antibody is given soon after delivery, it blocks the sensitization of the mother and prevents Rh disease from occurring in the woman’s next Rh-positive child.
Rhogam is given routinely to Rh-negative women after pregnancies in which they carried Rh-positive fetuses to prevent the mother’s immune system from reacting to the Rh-positive blood of any subsequent fetus.
Rhogam was developed in the 1960s by Dr. Vincent J. Freda (1927-2003), professor of obstetrics and gynecology at Columbia University.
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